HCID 18956522, compound → HCID 18956543, compound

HRID 1196933Notes

Reaction equation

HRID 1196933 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH:12]([C:14]2[N:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[CH3:13])[CH2:11][O:10]1.[Na].[NH:21]1[CH:25]=[N:24][CH:23]=[N:22]1.ClCCl.CO>CN(C)C=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:10])([CH:12]([C:14]1[N:15]=[N:16][CH:17]=[CH:18][CH:19]=1)[CH3:13])[CH2:11][N:21]1[CH:25]=[N:24][CH:23]=[N:22]1

Participants

5

Reactant 3

HCID 18956522HCID 18956522, compoundHCID 21226129Dichloromethane methanolHCID 454898221h-1,2,4-Triazole sodium salt

Product 1

HCID 18956543HCID 18956543, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Treatment of the product of part (iii) (1.15 g) with 1H-1,2,4-triazole sodium salt (0.80 g) in N,N-dimethylformamide (15 ml) according to the method of Example 1(ii), followed by chromatography of the crude product on silica gel using dichloromethane/methanol (50:1) as eluant, first gave, after combination and evaporation of appropriate fractions, the title compound, diastereoisomeric pair A, (0.35 g), m.p. 134°-135° (from ether).

Workup

  1. customfirst gave
  2. customafter combination and evaporation of appropriate fractions

Sources & evidence

ORD record
ord-3ed33b570bbd4ee2850de2a43d7b1862
Source dataset
uspto-grants-1992_05
Patent number
US05116844

Reaction notes

Loading…