Methyl iodide → 1-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

HRID 1196939Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1.I[CH3:19]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH:10]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH3:19]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 189565241-(2,4-Difluorophenyl)-2-(3-pyridinyl)-ethanone

Product 1

HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-oneYield 73.6%

Procedure

Methylation of the product of part (i) (5.0 g) with iodomethane (7.60 g) according to the method of Example 11(ii) gave the title compound as an oil (3.90 g) which was used directly in the next stage.

Sources & evidence

ORD record: ord-e3fe0713b35d4230a8b3914976606637
Source dataset: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05116844

Reaction notes

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