Hydrazine hydrate (1:1) → HCID 70043352, 화합물

HRID 1196950노트

반응식

HRID 1196950 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:28])([CH:16]([C:18]1[CH:23]=[CH:22][N:21]=[C:20]([C:24]([O:26]C)=O)[CH:19]=1)[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.O.[NH2:30][NH2:31]>C(O)(C)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:28])([CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1)[CH:16]([C:18]1[CH:23]=[CH:22][N:21]=[C:20]([C:24]([NH:30][NH2:31])=[O:26])[CH:19]=1)[CH3:17]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 19896865HCID 19896865, 화합물

생성물 1

HCID 70043352HCID 70043352, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A solution of the product of part (i) (3.80 g) and hydrazine hydrate (6.0 ml) in isopropanol (20 ml) was heated under reflux for 2.5 hours and then evaporated. Water was added to the residue and the mixture was extracted several times with dichloromethane. The combined extracts were washed with brine and dried (MgSO4). Evaporation of the solvent gave the title compound (3.30 g) as an amorphous foam which was used directly in the next stage.

후처리

  1. temperatureunder reflux for 2.5 hours
  2. customevaporated
  3. additionWater was added to the residue
  4. extractionthe mixture was extracted several times with dichloromethane
  5. washThe combined extracts were washed with brine
  6. dry with materialdried (MgSO4)
  7. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-8931323c250c46b38ac2153222efd217
출처 데이터셋
uspto-grants-1992_05
특허 번호
US05116844

반응 노트

불러오는 중…