反应详情

(Benzylthio)aniline (21.5 g, 0.1 mol) (the preparation of which has been described in Example 1 of U.S. Pat. No. 3,378,586) was reacted with 13.4 ml (0.1 mol) of phenylacetyl chloride in 135 ml of chloroform in the presence of 14.0 ml (0.1 mol) of triethylamine in the manner described under Example 1, part B, to give a solid residue. The latter was redissolved in 35 ml of warm chloroform and diluted with 150 ml of hexane. On seeding and rubbing, a crystalline solid gradually separated. After cooling overnight, the colorless solid was filtered, washed with hexane, and air-dried (22.3 g), m.p. 81°-83°. Following recrystallization from 350 ml of hexane, the title A material weighed 20.8 g, m.p. 82°-84°.

1. customto give a solid residue
2. customOn seeding and rubbing, a crystalline solid gradually separated
3. temperatureAfter cooling overnight
4. filtrationthe colorless solid was filtered
5. washwashed with hexane
6. customair-dried (22.3 g), m.p. 81°-83°
7. customrecrystallization from 350 ml of hexane