Hexane → HCID 14459226, compound

HRID 1197012Notes

Reaction equation

HRID 1197012 reaction equation
[Cl:1][C:2]1[C:3]([S:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]=2[Cl:21])=[CH:4][C:5]([F:9])=[C:6]([CH:8]=1)[NH2:7].[F:22][C:23]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:24]=1[C:25]([N:27]=[C:28]=[O:29])=[O:26].CCCCCC>C1(C)C=CC=CC=1>[F:22][C:23]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:24]=1[C:25]([NH:27][C:28]([NH:7][C:6]1[CH:8]=[C:2]([Cl:1])[C:3]([S:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][C:12]=2[Cl:21])=[CH:4][C:5]=1[F:9])=[O:29])=[O:26]

Participants

5

Reactant 3

HCID 8058HexaneHCID 27333692,6-Difluorobenzoyl isocyanateHCID 14459219HCID 14459219, compound

Product 1

HCID 14459226HCID 14459226, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

0.21 Gram of 5-chloro-2-fluoro-4-[2-chloro-4-(trifluoromethyl)phenylthio]aniline was dissolved in 6 ml of toluene, and to this solution was added dropwise a solution of 0.11 g of 2,6-difluorobenzoyl isocyanate in 4 ml of toluene with ice-cooling and stirring. After completion of addition, the reaction solution was stirred overnight at room temperature. Thereafter, 6 ml of n-hexane was added, the precipitated crystals were filtered off and dried to obtain 0.20 g of N-(2,6-difluorobenzoyl)-N'-[5-chloro-2-fluoro-4-{2-chloro-4-(trifluoromethyl)phenylthio}phenyl]urea as white crystals.

Workup

  1. temperaturecooling
  2. additionAfter completion of addition
  3. stirringthe reaction solution was stirred overnight at room temperature
  4. filtrationthe precipitated crystals were filtered off
  5. customdried

Sources & evidence

ORD record
ord-8133caa2ed9b40e08d6ed880185848d4
Source dataset
uspto-grants-1992_05
Patent number
US05116875

Reaction notes

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