反应详情

2-Bromothiophene (8.15 g, 0.05 mol), paraldehyde (2.20 g, 0.017 mol) and 4-isopropylbenzamide (1.63 g, 0.01 mol) were added to formic acid (10 ml) and stirred at a room temperature for three hours. Water (50 ml) was added to the reaction mixture. The mixture was extracted with chloroform (50 ml), subjected to a silica gel column chromatography (eluent: chloroform) and recrystallized from chloroform/petroleum benzine (1:2) to obtain the entitled compound (0.3 g) as a colorless needle-shape crystal. Yield: 8.5%. Melting point: 108° C.

1. extractionThe mixture was extracted with chloroform (50 ml)
2. customrecrystallized from chloroform/petroleum benzine (1:2)