反应详情

2-Ethylthiophene (5.60 g, 0.05 mol), paraldehyde (2.20 g, 0.017 mol) and 4-isopropylbenzamide (1.63 g, 0.01 mol) were added to a mixture of formic acid (6 ml) and 85% phosphoric acid (3 ml) and stirred at a room temperature for four hours. Water (50 ml) was added to the reaction mixture. The mixture was extracted with chloroform (50 ml) and subjected to a silica gel column chromatography (eluent: chloroform) to obtain the entitled compound (2.5 g) as a viscous yellow brown liquid. Yield: 83.1%.

1. extractionThe mixture was extracted with chloroform (50 ml)