HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1197157Generated: October 27, 2026
Methyl iodide → 2-O-Methyl-1,3-O,O-benzylideneglycerol
https://huagongshe.com/reaction/1197157
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1,3-Dioxan-5-ol, 2-phenyl- | HCID 74362 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-O-Methyl-1,3-O,O-benzylideneglycerol | HCID 128514 | 75% |
Reaction Steps
10 g of the sodium salt of 1b, obtained by reaction with sodium hydride in dimethylformamide, was treated with 16 g of methyl iodide. The mixture was stirred at 50° C. for 5 hours, and the dimethylformamide was eliminated in vacuo. The residue was dissolved in dichloromethane, washed and dried. The solvent was evaporated off and the product was chromatographed on silica gel (eluent : dichloromethane) to give 2b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05116992 |
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| Source dataset | uspto-grants-1992_05 |
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| ORD ID | ord-4eae467844f5405780d57ed7f81df576 |
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| Source note | uspto-grants-1992_05 |
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