反应详情

温度

50 °C

10 g of the sodium salt of 1b, obtained by reaction with sodium hydride in dimethylformamide, was treated with 16 g of methyl iodide. The mixture was stirred at 50° C. for 5 hours, and the dimethylformamide was eliminated in vacuo. The residue was dissolved in dichloromethane, washed and dried. The solvent was evaporated off and the product was chromatographed on silica gel (eluent : dichloromethane) to give 2b.

1. washwashed
2. customdried
3. customThe solvent was evaporated off
4. customthe product was chromatographed on silica gel (eluent : dichloromethane)