反应详情

温度

0 °C

4.2 g of 2b was dissolved in 10 ml of tetrahydrofuran at 0° C. A solution of BH3 in tetrahydrofuran (1M, 30 ml) was added slowly, under stirring. Stirring was continued for 48 hours at room temperature. The mixture was then cooled to 0° C., quenched with cold water and extracted with diethyl ether. The solvent was eliminated and the crude product was chromatographed (eluent petroleum ether/diethyl ether, successively 80:20 and 70:30 by volume), yielding 2.6 g of 3b (62%).

1. stirringStirring
2. customquenched with cold water
3. extractionextracted with diethyl ether
4. customthe crude product was chromatographed (eluent petroleum ether/diethyl ether, successively 80:20 and 70:30 by volume),