反应详情

To a solution of 5.88 g (30 mmol) of 3b and 10 ml of triethylamine in 100 ml of dry diethyl ether and 50 ml of dichloromethane, was added under stirring 6.84 g (60 mmol) of methanesulphonyl chloride in 50 ml of dichloromethane, and the mixture was refluxed for 5 hours. Water was then added, and the organic phase was decanted, dried and evaporated. The crude product was chromatographed (eluent petroleum ether/diethyl ether 80:20 by volume), to yield 6 g (74%) of 4b.

1. temperaturethe mixture was refluxed for 5 hours
2. customthe organic phase was decanted
3. customdried
4. customevaporated
5. customThe crude product was chromatographed (eluent petroleum ether/diethyl ether 80:20 by volume)