Pyridine → HCID 19897847, compound

HRID 1197160Notes

Reaction equation

HRID 1197160 reaction equation
[CH3:1][N:2]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:3][CH:4]([OH:26])[CH2:5][O:6][C:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.N1C=CC=CC=1.[CH3:51][N:52]=[C:53]=[O:54]>C1C=CC=CC=1>[CH3:1][N:2]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:3][CH:4]([O:26][C:53](=[O:54])[NH:52][CH3:51])[CH2:5][O:6][C:7]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 12228Methyl IsocyanateHCID 19897834HCID 19897834, compound

Product 1

HCID 19897847HCID 19897847, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 3-(N-methyl octadecylamino) 1-trityloxypropan-2-ol 6b (6 10-3M), pyridine (1 ml) and methylisocyanate (1.2 ml) in dry benzene (45 ml), was heated at 40° C. for three days. After elimination of the solvent, the residue was purified by column chromatography with CH2Cl2 as eluent, to give 7b.

Workup

  1. customAfter elimination of the solvent, the residue was purified by column chromatography with CH2Cl2 as eluent

Sources & evidence

ORD record
ord-a670df8e9bdb46e89e2402acd9fdf4a9
Source dataset
uspto-grants-1992_05
Patent number
US05116992

Reaction notes

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