Betahistine → HCID 67894947, compound

HRID 1197166Notes

Reaction equation

[CH:1]([CH2:3][CH2:4][C:5]12[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:6]1[C:7]([NH:9][C:10]2=[O:11])=[O:8])=O.[CH3:20][NH:21][CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1>>[CH3:20][N:21]([CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)[CH2:1][CH2:3][CH2:4][C:5]12[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:6]1[C:7]([NH:9][C:10]2=[O:11])=[O:8]

Participants

Reactant 2

HCID 2366Betahistine

HCID 19897748HCID 19897748, compound

Product 1

HCID 67894947HCID 67894947, compound

Procedure

Prepared from 2-(2-formyl-ethyl)-5,6-dimethoxy-phthalimide and 2-(2-methylamino-ethyl)-pyridine analogously to Example 4.

Sources & evidence

ORD record: ord-24c831eb576d49c8ac3b50b0e8f7dab5
Source dataset: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05116986

Reaction notes

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