1,4-Dimethoxybenzene → Benzophenone, 2,2',5-trimethoxy-

HRID 1197189Notes

Reaction equation

HRID 1197189 reaction equation
[C:1](Cl)(=[O:10])[C:2]1[C:3]([O:8][CH3:9])=[CH:4][CH:5]=[CH:6][CH:7]=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1>>[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9])=[O:10]

Participants

3

Reactant 2

HCID 90161,4-DimethoxybenzeneHCID 889692-Methoxybenzoyl chloride

Product 1

HCID 36279Benzophenone, 2,2',5-trimethoxy-

Conditions

Temperature
200 °C

Procedure

A mixture of o-anisoyl chloride (25.8 g, 0.15 mmol) and 1,4-dimethoxybenzene (37.2 g, 0.27 mol) was heated for 20 hours at 200° C., under N2. Distillation led to recovered 1,4-dimethoxybenzene (18.7 g), b.p. 232° C. (8 mm) followed by the title product, shown below, (25.4 g, 63%), b.p. 232° C. (7 mm) which was suitable for carrying forward to the next step. ##STR3##

Workup

  1. distillationDistillation
  2. customto recovered 1,4-dimethoxybenzene (18.7 g), b.p. 232° C. (8 mm)

Sources & evidence

ORD record
ord-60c5b63d54f94afa9db6efcd94c69946
Source dataset
uspto-grants-1992_05
Patent number
US05117009

Reaction notes

Loading…