2-Amino-2-methyl-1-propanol → HCID 70292693, compound

HRID 1197255Notes

Reaction equation

HRID 1197255 reaction equation
[C:1]([N:5]([C:19]([C:21]1[CH:22]=[C:23]([CH3:27])[CH:24]=[CH:25][CH:26]=1)=[O:20])[NH:6][C:7](=[O:18])[C:8]1[CH:13]=[CH:12][C:11]([C:14](OC)=O)=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:28][C:29]([CH3:33])([CH3:32])[CH2:30][OH:31]>CCOCC.C(Cl)Cl>[C:1]([N:5]([C:19]([C:21]1[CH:22]=[C:23]([CH3:27])[CH:24]=[CH:25][CH:26]=1)=[O:20])[NH:6][C:7](=[O:18])[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[O:31][CH2:30][C:29]([CH3:33])([CH3:32])[N:28]=2)=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 19368080HCID 19368080, compound

Product 1

HCID 70292693HCID 70292693, compound

Reagents, catalysts & solvents 1

HCID 21881112Ethyl ether methylene chlorideSolvent

Procedure

1.2 g of N'-t-butyl-N-(4-carbomethoxybenzoyl)-N'-(3-toluoyl)hydrazine was heated in 2 ml of 2-amino-2-methyl-1-propanol at 90°-100° C. for 5 hours. After cooling, the mixture was diluted with ether/methylene chloride and washed with 0.1N HCl. The organic layer was evaporated to afford 1.0 g of the corresponding amide.

Workup

  1. temperatureAfter cooling
  2. washwashed with 0.1N HCl
  3. customThe organic layer was evaporated

Sources & evidence

ORD record
ord-4fc4d90f31e742e690159525c76dcdc0
Source dataset
uspto-grants-1992_05
Patent number
US05117057

Reaction notes

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