反应详情

Dimethyl 1-acetylcyclohexane-1,4-dicarboxylate (23.3 g) was added to a solution of concentrated hydrochloric acid (253 ml) in ethanol (126 ml). After refluxing for 10 hours the reaction mixture was poured into water and then extracted with dichloromethane. The organic phase was then washed with saturate sodium bicarbonate solution and brine. After drying over anhydrous magnesium sulphate the solvent was removed under reduced pressure to give methyl 4-acetylcyclohexanecarboxylate as a colourless oil. This was purified by distillation (b.pt 138°-145° C. at 14 mmHg).

1. temperatureAfter refluxing for 10 hours the reaction mixture
2. extractionextracted with dichloromethane
3. washThe organic phase was then washed with saturate sodium bicarbonate solution and brine
4. dry with materialAfter drying over anhydrous magnesium sulphate the solvent
5. customwas removed under reduced pressure