反应详情

A mixture of 5-chloro-1-trimethylsilylpent-1-yne (13.5 g) and sodium iodide (29 g) in butanone (100 ml) was heated at reflux for 10 hours. After this time the solvent was removed in vacuo and the residue partitioned between diethyl ether and water. The organic phase was separated, washed with water and brine before drying over anhydrous magnesium sulphate. The solvent was removed under reduced pressure to leave 5-iodo-1-trimethylsilylpent-1-yne as a colourless oil (19.3 g).

1. temperaturewas heated
2. temperatureat reflux for 10 hours
3. customAfter this time the solvent was removed in vacuo
4. customthe residue partitioned between diethyl ether and water
5. customThe organic phase was separated
6. washwashed with water and brine
7. dry with materialbefore drying over anhydrous magnesium sulphate
8. customThe solvent was removed under reduced pressure