反应详情

温度

0 °C

At -5° to 0° C. and over a period of 15 minutes, 2.7 g (0.015 mol) of 30% strength sodium methylate was added, while stirring, to 2.95 g (0.015 mol) of 2-amino-4-fluoro-6-trifluoromethoxypyrimidine in 50 ml of methanol. The reaction mixture was stirred for 1 hour at 0° C., heated to 25° C., evaporated down under reduced pressure, stirred with water and extracted twice with methylene chloride. Drying and evaporation under reduced pressure gave 3.1 g (98% of theory) of the title compound; nD25 =1.4770.

1. temperatureheated to 25° C.
2. customevaporated down under reduced pressure
3. stirringstirred with water
4. extractionextracted twice with methylene chloride
5. customDrying
6. customevaporation under reduced pressure