Sodium Methoxide → 4-Methoxy-6-(trifluoromethoxy)pyrimidin-2-amine

Participants

Reaction Conditions

Reaction Steps

At -5° to 0° C. and over a period of 15 minutes, 2.7 g (0.015 mol) of 30% strength sodium methylate was added, while stirring, to 2.95 g (0.015 mol) of 2-amino-4-fluoro-6-trifluoromethoxypyrimidine in 50 ml of methanol. The reaction mixture was stirred for 1 hour at 0° C., heated to 25° C., evaporated down under reduced pressure, stirred with water and extracted twice with methylene chloride. Drying and evaporation under reduced pressure gave 3.1 g (98% of theory) of the title compound; nD25 =1.4770.

Provenance & Evidence