Dimethylamine → HCID 86747119, compound

Participants

Reaction Conditions

Reaction Steps

At 0° C. and over a period of 10 minutes, 1.9 g (0.0417 mol) of gaseous dimethylamine was added, while stirring, to a mixture of 8.9 g (0.0417 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoropyrimidine in 100 ml of tetrahydrofuran. The mixture was stirred for 1 hour at 0° C. and for 2 hours at 25° C. Conventional working up gave 9.7 g (97.5% of theory) of the title compound of melting point 127°-130° C.

Provenance & Evidence