Dimethylamine → HCID 86747119, compound

HRID 1197418Notes

Reaction equation

[CH3:1][NH:2][CH3:3].[NH2:4][C:5]1[N:10]=[C:9]([Cl:11])[C:8]([O:12][CH:13]([F:15])[F:14])=[C:7](F)[N:6]=1.O1CCC[CH2:18]1>>[Cl:11][C:9]1[C:8]([O:12][CH:13]([F:15])[F:14])=[C:7]([N:2]([CH3:3])[CH3:1])[N:6]=[C:5]([NH:4][CH3:18])[N:10]=1

Participants

Reactant 3

HCID 674Dimethylamine

HCID 8028Tetrahydrofuran

HCID 21996901HCID 21996901, compound

Product 1

HCID 86747119HCID 86747119, compound

Conditions

Temperature: 25 °C

Procedure

At 0° C. and over a period of 10 minutes, 1.9 g (0.0417 mol) of gaseous dimethylamine was added, while stirring, to a mixture of 8.9 g (0.0417 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoropyrimidine in 100 ml of tetrahydrofuran. The mixture was stirred for 1 hour at 0° C. and for 2 hours at 25° C. Conventional working up gave 9.7 g (97.5% of theory) of the title compound of melting point 127°-130° C.

Sources & evidence

ORD record: ord-28e1baf891564bad8351843f8a056972
Source dataset: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05276007

Reaction notes

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