1-Amino-2-propanethiol hydrochloride → HCID 19106459, compound

HRID 1197432Notes

Reaction equation

HRID 1197432 reaction equation
Cl[C:2]1([S:12]([NH2:15])(=[O:14])=[O:13])[CH:6](C(OCC)=O)[CH:5]=[CH:4][S:3]1.Cl.[NH2:17][CH2:18][CH:19]([SH:21])[CH3:20].[O-:22][CH2:23]C.[Na+]>>[CH3:20][CH:19]1[CH2:18][NH:17][C:23](=[O:22])[C:5]2[CH:6]=[C:2]([S:12](=[O:13])(=[O:14])[NH2:15])[S:3][C:4]=2[S:21]1

Participants

4

Reactant 3

HCID 1457271-Amino-2-propanethiol hydrochlorideHCID 2723922Sodium ethoxideHCID 19106453HCID 19106453, compound

Product 1

HCID 19106459HCID 19106459, compoundYield 51%

Procedure

Following the procedure described in Example 1, Step E, 2-chloro-3-carboethoxythiophene-2-sulfonamide was reacted with 1-amino-2-propanethiol hydrochloride in the presence of four equivalents of sodium ethoxide to give, after recrystallization from ethyl acetate, a 51% yield of title compound, mp 199°-201° C.

Workup

  1. customto give
  2. customafter recrystallization from ethyl acetate

Sources & evidence

ORD record
ord-0e25dc0009a14054a9cdf6acbc70be52
Source dataset
uspto-grants-1994_01
Patent number
US05276025

Reaction notes

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