反应详情

A ground mixture of 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-4,5-dihydro-4-oxo-imidazo[1,5-a]quinoxaline (3.76 g, 13 mmol) and phosphorus pentachloride (2.67 g, 13 mmol) in phosphorus oxychloride (10 ml) was stirred for 2 h at 150°-160° C. The resulting solution while still warm was poured into 200 ml of ice and stirred for 1 h. The precipitate was collected by filtration, rinsed with water and dried to give 3.4 g of the title compound, m.p. 140°-150° C. (dec.). The crude product obtained in this way was processed without further purification. (Compound 1).

1. temperatureThe resulting solution while still warm
2. stirringstirred for 1 h
3. filtrationThe precipitate was collected by filtration
4. washrinsed with water
5. customdried