HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1197450Generated: October 25, 2026
4-Chlorophenyl Isocyanate → 1-(p-Chlorophenyl)-3-(3,4-dihydro-2-methyl-4-oxo-3-quinazolinyl)urea
https://huagongshe.com/reaction/1197450
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chlorophenyl Isocyanate | HCID 7693 | — |
| Reactant | 3-amino-2-methylquinazolin-4(3H)-one | HCID 237591 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 1-(p-Chlorophenyl)-3-(3,4-dihydro-2-methyl-4-oxo-3-quinazolinyl)urea | HCID 19106817 | — |
Reaction Steps
A mixture of 3-amino-2-methyl-4-quinazolone (1.60 g, 9.10 mmol) and 4-chlorophenyl isocyanate (1.54 g, 10.0 mmol) in 1,2-dichloroethane is heated at reflux for 22 hours, concentrated in vacuo, cooled to 0° C. and filtered. The filter cake is washed with ether and dried to give the title product as a white solid, 2.45 g (82%), mp 228°-229.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05276038 |
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| Source dataset | uspto-grants-1994_01 |
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| ORD ID | ord-32192ca57fd847f0887d1eaa6b97324b |
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| Source note | uspto-grants-1994_01 |
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