4-Chlorophenyl Isocyanate → 1-(p-Chlorophenyl)-3-(3,4-dihydro-2-methyl-4-oxo-3-quinazolinyl)urea

HRID 1197450Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1197450
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[CH3:13].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]=[C:22]=[O:23])=[CH:17][CH:16]=1>ClCCCl>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:1][N:2]2[C:11](=[O:12])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[N:4]=[C:3]2[CH3:13])=[O:23])=[CH:17][CH:16]=1

Komponenten

4

Edukt 2

HCID 76934-Chlorophenyl IsocyanateHCID 2375913-amino-2-methylquinazolin-4(3H)-one

Produkt 1

HCID 191068171-(p-Chlorophenyl)-3-(3,4-dihydro-2-methyl-4-oxo-3-quinazolinyl)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 3-amino-2-methyl-4-quinazolone (1.60 g, 9.10 mmol) and 4-chlorophenyl isocyanate (1.54 g, 10.0 mmol) in 1,2-dichloroethane is heated at reflux for 22 hours, concentrated in vacuo, cooled to 0° C. and filtered. The filter cake is washed with ether and dried to give the title product as a white solid, 2.45 g (82%), mp 228°-229.5° C.

Aufarbeitung

  1. temperatureis heated
  2. temperatureat reflux for 22 hours
  3. concentrationconcentrated in vacuo
  4. filtrationfiltered
  5. washThe filter cake is washed with ether
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-32192ca57fd847f0887d1eaa6b97324b
Quelldatensatz
uspto-grants-1994_01
Patentnummer
US05276038

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