Hydrochloric Acid → HCID 21254478, compound

HRID 1197464Notes

Reaction equation

HRID 1197464 reaction equation
C(O)(=O)/C=C/C(O)=O.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.[ClH:15]>C(O)C>[ClH:15].[ClH:15].[ClH:15].[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 650854114396-14-6

Product 1

HCID 21254478HCID 21254478, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5 g of 1-diphenylmethyl-4-[2-(-4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl]piperazine monofumarate were dissolved in 100 ml of hot ethanol. 3 ml of commercial concentrated HCl solution (10N) were added with stirring. The solution was refluxed for 30 minutes then the solution was allowed to cool to room temperature. The solvent was evaporated off and the residue was crystallized twice from ethanol at 98° C. to yield 1-diphenylmethyl-4-[2-(-4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl]piperazine trihydrochloride, m.p. 202°-204° with decomposition.

Workup

  1. temperatureThe solution was refluxed for 30 minutes
  2. customThe solvent was evaporated off
  3. customthe residue was crystallized twice from ethanol at 98° C.

Sources & evidence

ORD record
ord-411a9b3c575340329b3ad805a018be2e
Source dataset
uspto-grants-1994_01
Patent number
US05276034

Reaction notes

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