Hydrochloric Acid → HCID 14540321, compound

HRID 1197471Notes

Reaction equation

HRID 1197471 reaction equation
C([O:3][C:4](=[O:16])[C@@H:5]([CH2:10][C:11]1[N:12]=[CH:13][S:14][CH:15]=1)[NH:6]C(=O)C)C.[ClH:17]>>[ClH:17].[ClH:17].[S:14]1[CH:15]=[C:11]([CH2:10][C@@H:5]([C:4]([OH:16])=[O:3])[NH2:6])[N:12]=[CH:13]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14840794HCID 14840794, compound

Product 1

HCID 14540321HCID 14540321, compound

Procedure

A 2 L round bottom flask equipped with a magnetic stirrer was charged with N-acetyl-3-(4-thialzoyl)-L-alanine from Example 3L (92.6 g, 0.43 mol) and 6M HCl (1 L). The resultant solution was heated to reflux. After 3 h the mixture was allowed to cool to room temperature. The solution was then concentrated under reduced pressure, evaporated from toluene (3×200 mL), and dried under vacuum overnight to give 120 g of a slightly wet solid. This material was used in the next reaction without further purification.

Workup

  1. customA 2 L round bottom flask equipped with a magnetic stirrer
  2. concentrationThe solution was then concentrated under reduced pressure
  3. customevaporated from toluene (3×200 mL)
  4. customdried under vacuum overnight
  5. customto give 120 g of a slightly wet solid
  6. customThis material was used in the next reaction without further purification

Sources & evidence

ORD record
ord-92049ac2fc0746a5a42507d3b97e5f2a
Source dataset
uspto-grants-1994_01
Patent number
US05276031

Reaction notes

Loading…