Ethanol → HCID 19106831, compound

HRID 1197479Notes

Reaction equation

HRID 1197479 reaction equation
C(O)C.[CH2:4]=[C:5]1[CH2:13][CH2:12][C:8]2[S:9][CH:10]=[CH:11][C:7]=2[C:6]1=O.O.[NH2:16][NH2:17]>O>[N:16]1[NH:17][CH2:4][CH:5]2[C:6]=1[C:7]1[CH:11]=[CH:10][S:9][C:8]=1[CH2:12][CH2:13]2

Participants

5

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 19106822HCID 19106822, compound

Product 1

HCID 19106831HCID 19106831, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 20 mL of anhydrous ethanol was added 1.2 g of the product from Step A and 0.40 g of hydrazine hydrate. The reaction mixture was heated at reflux for 2 h, cooled, poured into cold water and extracted with ether. The ether extracts were washed with water and brine, dried over anhydrous magnesium sulfate, filtered and utilized without concentration or purification in Step C.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 2 h
  3. temperaturecooled
  4. extractionextracted with ether
  5. washThe ether extracts were washed with water and brine
  6. dry with materialdried over anhydrous magnesium sulfate
  7. filtrationfiltered
  8. concentrationutilized without concentration or purification in Step C

Sources & evidence

ORD record
ord-978a89b5c35341f3985494ff1a1bdfee
Source dataset
uspto-grants-1994_01
Patent number
US05276039

Reaction notes

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