Hydrochloric Acid → HCID 14540321, compound

HRID 1197502Notes

Reaction equation

HRID 1197502 reaction equation
C([NH:4][C@H:5]([C:12]([OH:14])=[O:13])[CH2:6][C:7]1[N:8]=[CH:9][S:10][CH:11]=1)(=O)C.[ClH:15]>>[ClH:15].[ClH:15].[S:10]1[CH:11]=[C:7]([CH2:6][C@@H:5]([C:12]([OH:14])=[O:13])[NH2:4])[N:8]=[CH:9]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 15018093HCID 15018093, compound

Product 1

HCID 14540321HCID 14540321, compound

Procedure

A 2 L round bottom flask equipped with a magnetic stirrer was charged with N-acetyl-3-(4-thiazolyl)-L-alanine from Example 1L (92.6 g, 0.43 mol) and 6M hydrochloric acid (1 L). The resultant solution was heated to reflux. After 3 hours the mixture was allowed to cool to ambient temperature. The solution was then concentrated under reduced pressure, evaporated from toluene (3×200 mL), and dried under vacuum overnight to give 120 g of a slightly wet solid. This material was used in the next reaction without further purification.

Workup

  1. customA 2 L round bottom flask equipped with a magnetic stirrer
  2. concentrationThe solution was then concentrated under reduced pressure
  3. customevaporated from toluene (3×200 mL)
  4. customdried under vacuum overnight
  5. customto give 120 g of a slightly wet solid
  6. customThis material was used in the next reaction without further purification

Sources & evidence

ORD record
ord-40546031fb5f483481c53133c73ed3a6
Source dataset
uspto-grants-1994_01
Patent number
US05275950

Reaction notes

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