HCID 19106972, compound → HCID 19107117, compound

HRID 1197538Notes

Reaction equation

HRID 1197538 reaction equation
[CH:1]1[C:10]2[C:9]3([C:15]([O:17]CC)=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH:8]3[CH2:7][O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.C[Si](C)(C)[O-].[K+]>C1COCC1>[CH:1]1[C:10]2[C:9]3([C:15]([OH:17])=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH:8]3[CH2:7][O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 19106972HCID 19106972, compoundHCID 23668039Potassium trimethylsilanolate

Product 1

HCID 19107117HCID 19107117, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the compound from Example 69 (4.9 g, 18.6 mmol) and potassium trimethylsilanolate (4.5 g) in 75 ml THF was refluxed for 23 hours. Workup as previously described gave the title compound as a white solid (4.25 g).

Sources & evidence

ORD record
ord-35741bc00c1a4c21b4311f89c52ad69c
Source dataset
uspto-grants-1994_01
Patent number
US05276053

Reaction notes

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