Hydrochloric Acid → HCID 19107094, compound

HRID 1197541Notes

Reaction equation

HRID 1197541 reaction equation
COC(=O)[NH:4][C:5]12[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[CH2:9][O:8][C:7]1[CH:15]=[CH:16][CH:17]=[CH:18][C:6]2=1.C[Si](C)(C)[O-].[K+].[ClH:26]>>[ClH:26].[CH:18]1[C:6]2[C:5]3([NH2:4])[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]3[CH2:9][O:8][C:7]=2[CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 23668039Potassium trimethylsilanolateHCID 131717093HCID 131717093, compound

Product 1

HCID 19107094HCID 19107094, compound

Procedure

A solution of the compound from Example 72 (0.3 g, 1.15 mmol) and potassium trimethylsilanolate (0.3 g, 2.34 mmol) was refluxed for 21 hours. Workup followed by treatment of the free amine with isopropanolic HCl gave the title compound (0.24 g), mp 230°-232° C.

Sources & evidence

ORD record
ord-4a0e7e8ae72b4f169e050240d06ac4de
Source dataset
uspto-grants-1994_01
Patent number
US05276053

Reaction notes

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