反应详情

2.76 g (20 mmol) of 1-pyridyl-2-propanone and 3.066 g (20 mmol) of 3-nitrobenzaldehyde were dissolved in benzene. To this solution, 0.29 g (2.0 mmol) of piperidinium acetate was added, and the mixture was refluxed with application of heat for 6 hours for dehydration. The reaction mixture was washed with water, and dried over anhydrous sodium sulfate. The benzene contained in the reaction mixture was distilled off under reduced pressure and the remaining reaction product was chromatographed on a silica gel column, whereby the captioned compound was obtained. The yield was 4.5 g (87.9%).

1. temperaturethe mixture was refluxed with application
2. temperatureof heat for 6 hours for dehydration
3. washThe reaction mixture was washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. distillationwas distilled off under reduced pressure
6. customthe remaining reaction product
7. customwas chromatographed on a silica gel column, whereby the captioned compound
8. customwas obtained