Ammonia → N-Cyclohexyl-2-pyrrolidone

HRID 1197672Notes

Reaction equation

HRID 1197672 reaction equation
[CH:1]1([NH:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)CC[CH2:4][CH2:3][CH2:2]1.N.[H][H].[O:17]1CCCC1>>[CH:8]1([N:7]2[CH2:4][CH2:3][CH2:2][C:1]2=[O:17])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

5

Reactant 4

HCID 222AmmoniaHCID 7582DicyclohexylamineHCID 8028TetrahydrofuranHCID 178418361HCID 178418361, compound2×

Product 1

HCID 81278N-Cyclohexyl-2-pyrrolidoneYield 8.8%

Conditions

Temperature
225 °C

Procedure

5 g (0.05 mol) of MAA, 100 g of tetrahydrofuran, 9 g (0.06 mol) of dicyclohexylamine, 4 g of ammonia and 10 g of catalyst B were introduced into an autoclave fitted with a gas-distribution stirrer. The autoclave was subsequently heated to 225° C., and hydrogen was injected into the autoclave at a pressure of 200 bar. When take-up of hydrogen was no longer observed, the reaction was terminated. Analysis of the reaction mixture by gas chromatography gave a yield of 8.8% of N-cyclohexylpyrrolidone.

Workup

  1. customfitted with a gas-distribution stirrer
  2. customthe reaction was terminated

Sources & evidence

ORD record
ord-182688f1bd6a48e180897be17e34f026
Source dataset
uspto-grants-1994_01
Patent number
US05276165

Reaction notes

Loading…