Triethyl phosphite → Diethyl 2-formylbenzylphosphonate

HRID 1197746Notes

Reaction equation

HRID 1197746 reaction equation
Cl[CH2:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[O:6].[P:11]([O:18]CC)([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14]>>[CH:5]([C:4]1[CH:7]=[CH:8][CH:9]=[CH:10][C:3]=1[CH2:2][P:11](=[O:18])([O:15][CH2:16][CH3:17])[O:12][CH2:13][CH3:14])=[O:6]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 138261832-(Chloromethyl)benzaldehyde

Product 1

HCID 19104780Diethyl 2-formylbenzylphosphonate

Procedure

47.9 g (0.31 mol) of 2-chloromethylbenzaldehyde were heated to 160° C. together with 51.5 g (0.31 mol) of triethyl phosphite. Ethyl chloride distilled off during the course of this. The product was purified by fractional distillation.

Workup

  1. distillationEthyl chloride distilled off during the course of this
  2. distillationThe product was purified by fractional distillation

Sources & evidence

ORD record
ord-cc0f8c24a4c24503889bed2effd1d700
Source dataset
uspto-grants-1994_01
Patent number
US05278152

Reaction notes

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