Acetic Acid → Diethyl 2-formylbenzylphosphonate thiosemicarbazone

HRID 1197747Notes

Reaction equation

HRID 1197747 reaction equation
[CH:1]([C:3]1[CH:17]=[CH:16][CH:15]=[CH:14][C:4]=1[CH2:5][P:6](=[O:13])([O:10][CH2:11][CH3:12])[O:7][CH2:8][CH3:9])=O.[NH2:18][NH:19][C:20]([NH2:22])=[S:21].C(O)(=O)C>C(O)C>[CH:1](=[N:18][NH:19][C:20]([NH2:22])=[S:21])[C:3]1[CH:17]=[CH:16][CH:15]=[CH:14][C:4]=1[CH2:5][P:6](=[O:13])([O:10][CH2:11][CH3:12])[O:7][CH2:8][CH3:9]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 2723789ThiosemicarbazideHCID 19104780Diethyl 2-formylbenzylphosphonate

Product 1

HCID 53896642Diethyl 2-formylbenzylphosphonate thiosemicarbazone

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.0 g (8 mmol) of the compound A and 0.73 g of thiosemicarbazide were dissolved or suspended in 200 ml of absolute ethanol. 2 ml of acetic acid were added and the mixture was boiled under reflux for 3 h. In the course of the slow cooling, the product D precipitated in crystalline form.

Workup

  1. temperatureunder reflux for 3 h
  2. customIn the course of the slow cooling, the product D precipitated in crystalline form

Sources & evidence

ORD record
ord-3b6b3d1703714625b1121304484cd5ea
Source dataset
uspto-grants-1994_01
Patent number
US05278152

Reaction notes

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