Dimethylformamide → HCID 19104991, compound

HRID 1197781Notes

Reaction equation

HRID 1197781 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[CH:12]=[C:11](Cl)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16]([OH:20])[CH2:17][CH2:18][OH:19].[OH-].[K+].CN(C)C=O>O>[CH2:1]([N:8]1[C:13](=[O:14])[CH:12]=[C:11]([O:19][CH2:18][CH2:17][CH2:16][OH:20])[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 104421,3-PropanediolHCID 14797Potassium HydroxideHCID 19104992HCID 19104992, compound

Product 1

HCID 19104991HCID 19104991, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The mixture of 10 g of 2-benzyl-5-chloro-3(2H)-pyridazinone, 50 g of 1,3-propanediol, 3.0 g of 85 % potassium hydroxide and 50 ml of N,N-dimethylformamide was reacted for 24 hours at room temperature, then to the reaction solution was added water and extracted with ethyl acetate, dried and freed of solvent to obtain 9.4 g of the intended compound.

Workup

  1. customwas reacted for 24 hours at room temperature
  2. extractionextracted with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-a96f5906d0bb47ac97a2e6d03488f38f
Source dataset
uspto-grants-1994_01
Patent number
US05278163

Reaction notes

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