Propylamine → HCID 19761474, compound

HRID 1197786Notes

Reaction equation

HRID 1197786 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([CH2:11][NH2:12])[CH2:7][C:8](Cl)=[O:9].[CH2:13]([NH2:16])[CH2:14][CH3:15]>C(Cl)(Cl)Cl>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([CH2:11][NH2:12])[CH2:7][C:8]([NH:16][CH2:13][CH2:14][CH3:15])=[O:9]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 54532498HCID 54532498, compound

Product 1

HCID 19761474HCID 19761474, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

0.01 mol of the compound obtained in stage A of Example 16 is dissolved in 50 cm3 of chloroform. 0.025 mol of propylamine is added and the whole is heated under reflux for 5 hours while stirring and then cooled. The reaction mixture is then evaporated to dryness and extracted twice with chloroform. The chloroform phases are combined and dried over calcium chloride and the solvent is evaporated in vacuo on a water bath. The residue is purified by chromatography.

Workup

  1. temperaturethe whole is heated
  2. temperatureunder reflux for 5 hours
  3. temperaturecooled
  4. customThe reaction mixture is then evaporated to dryness
  5. extractionextracted twice with chloroform
  6. dry with materialdried over calcium chloride
  7. customthe solvent is evaporated in vacuo on a water bath
  8. customThe residue is purified by chromatography

Sources & evidence

ORD record
ord-caede1cee55b4c85aaea039d1099a6c9
Source dataset
uspto-grants-1994_01
Patent number
US05278166

Reaction notes

Loading…