Diethyl Malonate → HCID 19104967, compound

HRID 1197796Notes

Reaction equation

[NH:1]([C:3]1[C:8]([CH2:9][CH:10]([CH3:12])[CH3:11])=[N:7][C:6]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:5][N:4]=1)[NH2:2].[C:19](OCC)(=O)[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[CH2:9]([C:8]1[C:3]2[N:4]([C:19]([CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[N:2][N:1]=2)[CH:5]=[C:6]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:7]=1)[CH:10]([CH3:12])[CH3:11]

Participants

Reactant 2

HCID 7761Diethyl Malonate

HCID 19104970HCID 19104970, compound

Product 1

HCID 19104967HCID 19104967, compound

Procedure

In a manner analogous to Example 1, by condensing 2-hydrazino-3-isobutyl-5-(3-pyridyl)pyrazine with diethyl malonate there is obtained ethyl 8-isobutyl-6-(3-pyridyl)-s-triazolo[4,3-a]pyrazine-3-acetate, MS: 339 (M)+, which is converted by saponification into the above acid: MS 267 (M-CO2)+.

Sources & evidence

ORD record: ord-764ebf309c9b4bba981a56390c83e416
Source dataset: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05278161

Reaction notes

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