Diethyl Malonate → HCID 19104974, compound

HRID 1197799Notes

Reaction equation

[CH2:1]([C:8]1[C:13]([NH:14][NH2:15])=[N:12][CH:11]=[C:10]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:22](OCC)(=O)[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[CH2:1]([C:8]1[C:13]2[N:12]([C:22]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[N:15][N:14]=2)[CH:11]=[C:10]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 7761Diethyl Malonate

HCID 19104951HCID 19104951, compound

Product 1

HCID 19104974HCID 19104974, compound

Procedure

In a manner analogous to Example 1, by condensing 2-benzyl-3-hydrazino-6-(3-pyridyl)pyrazine with diethyl malonate there is obtained ethyl 8-benzyl-6-(3-pyridyl)-s-triazolo[4,3-a]pyrazine-3-acetate, which is converted by basic saponification into the above acid, MS: 301 (M-CO2)+.

Sources & evidence

ORD record: ord-1d803cedb5e641e682d39a147316df38
Source dataset: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05278161

Reaction notes

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