Diethyl Malonate → HCID 19104916, compound

HRID 1197801Notes

Reaction equation

[CH2:1]([C:8]1[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:11]=[N:10][C:9]=1[NH:20][NH2:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:22](OCC)(=O)[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[CH2:1]([C:8]1[C:9]2[N:10]([C:22]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[N:21][N:20]=2)[N:11]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7761Diethyl Malonate

HCID 12391765HCID 12391765, compound

Product 1

HCID 19104916HCID 19104916, compound

Procedure

In a manner analogous to that described in Example 1, by the ring condensation of 4-benzyl-3-hydrazino-6-phenyl-pyridazine [Indian J. Chem., 15B, 352 (1977)] with diethyl malonate there is obtained ethyl 8-benzyl-6-phenyl-s-triazolo[4,3-b]pyridazine-3-acetate, MS: 372 (M)+, which is saponified with a base to the above acid, MS: 316 (M-CO)+.

Sources & evidence

ORD record: ord-0c045ed2fc584b02af3c3c166181be1f
Source dataset: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05278161

Reaction notes

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