Diethyl methylmalonate → HCID 57145264, compound

HRID 1197809Notes

Reaction equation

[NH:1]([C:3]1[C:8]([CH:9]([CH3:12])[CH2:10][CH3:11])=[N:7][C:6]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:5][N:4]=1)[NH2:2].[CH3:19][CH:20]([C:26](OCC)=O)[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[CH3:19][CH:20]([C:26]1[N:4]2[CH:5]=[C:6]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)[N:7]=[C:8]([CH:9]([CH3:12])[CH2:10][CH3:11])[C:3]2=[N:1][N:2]=1)[C:21]([O:23][CH2:24][CH3:25])=[O:22]

Participants

Reactant 2

HCID 11857Diethyl methylmalonate

HCID 19104896HCID 19104896, compound

Product 1

HCID 57145264HCID 57145264, compound

Procedure

In a manner analogous to that described in Example 1, by condensing 2-hydrazino-3-[(RS)-1-methylpropyl]-5-(3-pyridyl)pyrazine with diethyl methylmalonate there is obtained ethyl rac-α-methyl-8-[(RS)-1-methylpropyl]-6-(3-pyridyl)-s-triazolo[4,3-a]pyrazine-3-acetate, MS: 353 (M)+, which by saponification analogously to Example 1 is converted into the above acid which is used directly in the next step.

Sources & evidence

ORD record: ord-2278f2aa9a1a43efb5d2d1e5a053f64a
Source dataset: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05278161

Reaction notes

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