反应详情

3 ml of triethylamine were added at ambient temperature to a solution of 2 equivalents of -lactic acid hydrazide in 60 ml of toluene and then, 4.3 g of N-(4-methoxyphenyl)-4-nitrobenzene carboximidoyl chloride (Step A of Example 1) were added in two lots with stirring for 4 hours at ambient temperature. The mixture was then refluxed for 4 hours to obtain cyclization and the toluene was eliminated under reduced pressure. After washing with water, filtering and drying, 4.34 g of crude product were obtained which was purified by chromatography under pressure (eluent-chloroform-ethyl acetate-methanol: 47:50:3) to obtain 3 g of 5-[4-nitrophenyl]-4-(4-methoxyphenyl)-methyl-4H-1,2,4-triazol-3-methanol melting at 140° C.

1. temperatureThe mixture was then refluxed for 4 hours
2. customto obtain cyclization
3. washAfter washing with water
4. filtrationfiltering
5. customdrying
6. custom4.34 g of crude product were obtained which
7. customwas purified by chromatography under pressure (eluent-chloroform-ethyl acetate-methanol: 47:50:3)