Triethylamine → 3,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole

HRID 1197874Notes

Reaction equation

HRID 1197874 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10](Cl)[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1.[C:20]([NH:24][NH2:25])(=O)[CH2:21][CH3:22].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]2[N:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[C:20]([CH2:21][CH3:22])=[N:24][N:25]=2)=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 79890PropionylhydrazineHCID 12293818N-(4-methoxyphenyl)-4-methoxybenzene carboximidoyl chloride

Product 1

HCID 130540183,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazoleYield 72.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Using the procedure of Step B, of Example 4, 3.46 g of the product of Step A, 2.21 g of propionic acid hydrazide, 1.74 ml of triethylamine and 50 ml of toluene were reacted to obtain 2.8 g of 3,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole melting at 122° C.

Sources & evidence

ORD record
ord-7d8a277a36df476883c8b48d5bada100
Source dataset
uspto-grants-1994_01
Patent number
US05278180

Reaction notes

Loading…