p-Toluenesulfonic acid monohydrate → HCID 19016867, compound

HRID 1197917Notes

Reaction equation

HRID 1197917 reaction equation
[CH2:1]([CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[CH3:12])[CH:4]1[OH:13])[CH3:2].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH2:1]([CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[CH3:12])[C:4]1=[O:13])[CH3:2]

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 19105429HCID 19105429, compound

Product 1

HCID 19016867HCID 19016867, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The non-purified 2-ethyl-4-methyl-1-indanol was treated on a steam bath in 700 ml of toluene in the presence of 0.75 g of p-toluenesulfonic acid monohydrate for 2 hours. The solvent mixture was removed in vacuo, the residue was taken up in ether, and the mixture was washed with saturated NaHCO3 solution and NaCl solution and dried over MgSO4. The solvent was removed in vacuo and the residue was distilled (62° C./0.2 mmHg).

Workup

  1. customThe solvent mixture was removed in vacuo
  2. washthe mixture was washed with saturated NaHCO3 solution and NaCl solution
  3. dry with materialdried over MgSO4
  4. customThe solvent was removed in vacuo
  5. distillationthe residue was distilled (62° C./0.2 mmHg)

Sources & evidence

ORD record
ord-d39fed8505d140ca864b5acd5e101fb9
Source dataset
uspto-grants-1994_01
Patent number
US05278264

Reaction notes

Loading…