Potassium Carbonate → HCID 178447084, compound

Participants

Reaction Steps

In an analogous manner to that described in Example 4, (S)-N-[(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-3-(2-oxo-1-piperidinyl)propyl]-α-[(R)-α-(3,3-dimethyl-2-oxobutyl)hy drocinnamamido]-3-t butoxycarbonylimidazole-4-propionamide was treated with potassium carbonate in methanol, whereby there was obtained (S)-N-[(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-3-(2-oxopiperidino)propyl]-α-[(R)-α-(3,3-dimethyl-2-oxobutyl)hydrocinnamamido]imidazole-4propionamide as an amorphous solid, MS: 636 (M+H)+.

Provenance & Evidence