Potassium Carbonate → HCID 178447084, compound

HRID 1197931Notes

Reaction equation

HRID 1197931 reaction equation
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:53])[C@@H:21]([NH:35][C:36](=[O:52])[C@@H:37]([CH2:45][C:46](=[O:51])[C:47]([CH3:50])([CH3:49])[CH3:48])[CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH2:22][C:23]2[N:24](C(OC(C)(C)C)=O)[CH:25]=[N:26][CH:27]=2)[C@@H:9]([OH:18])[CH2:10][N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]2=[O:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:53])[C@@H:21]([NH:35][C:36](=[O:52])[C@@H:37]([CH2:45][C:46](=[O:51])[C:47]([CH3:49])([CH3:50])[CH3:48])[CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH2:22][C:23]2[N:24]=[CH:25][NH:26][CH:27]=2)[C@@H:9]([OH:18])[CH2:10][N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][C:12]2=[O:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 70066304HCID 70066304, compound

Product 1

HCID 178447084HCID 178447084, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to that described in Example 4, (S)-N-[(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-3-(2-oxo-1-piperidinyl)propyl]-α-[(R)-α-(3,3-dimethyl-2-oxobutyl)hy drocinnamamido]-3-t butoxycarbonylimidazole-4-propionamide was treated with potassium carbonate in methanol, whereby there was obtained (S)-N-[(1S,2S)-1-(cyclohexylmethyl)-2-hydroxy-3-(2-oxopiperidino)propyl]-α-[(R)-α-(3,3-dimethyl-2-oxobutyl)hydrocinnamamido]imidazole-4propionamide as an amorphous solid, MS: 636 (M+H)+.

Sources & evidence

ORD record
ord-848a2e6d2cb349e49be2ccb9dd79ba23
Source dataset
uspto-grants-1994_01
Patent number
US05278148

Reaction notes

Loading…