Dabco → HCID 9886772, compound

HRID 1198037Notes

Reaction equation

HRID 1198037 reaction equation
C(O[C:4](=[O:19])[CH2:5][C:6](=[O:18])[C:7]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9][CH2:8]1)C.[N:20]12[CH2:27][CH2:26]N(CC1)CC2>>[CH3:13][CH:12]([C:7]1[CH:6]=[CH:5][CH:4]=[C:26]([CH:9]([CH3:10])[CH3:8])[C:27]=1[NH:20][C:4](=[O:19])[CH2:5][C:6](=[O:18])[C:7]1([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:8][CH2:9][CH2:10][CH2:11]1)[CH3:17]

Participants

3

Reactant 2

HCID 9237DabcoHCID 10422730HCID 10422730, compound

Product 1

HCID 9886772HCID 9886772, compound

Procedure

The title compound was prepared from β-oxo-1-phenylcyclopentanepropanoic acid ethyl ester (8.0 g, 0.03 mol), 1,4-diazabicyclo[2.2.2]octane (34.4 g, 0.30 mol) and xylenes (54.8 ML, 15.0 eq) using the procedure described in Example 3, Step B. 1H NMR (ppm, CDCl3): 1.62-1.73 (m, 4H), 1.85-1.90 (m, 2H), 1.93 (s, 3H, CH3), 2.43-2.52 (m, 2H), 7.20-7.36 (m, 5H).

Sources & evidence

ORD record
ord-784478327dca45a48553aa1f0a4ebadd
Source dataset
uspto-grants-1994_01
Patent number
US05278326

Reaction notes

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