HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluoroacetophenone → 2,4-difluoro-N-octyl-beta-oxo-benzenepropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluoroacetophenone | HCID 67770 | — |
| Reactant | Octyl isocyanate | HCID 76616 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Product | 2,4-difluoro-N-octyl-beta-oxo-benzenepropanamide | HCID 19105587 | 42.6% |
Reaction Steps
The title compound was prepared from 2',4'-difluoroacetophenone (5.0 g, 0.032 mol), octyl isocyanate (4.97 g, 0.032 mol), and lithium diisopropylamide (0.032 mol) using the procedure described in Example 1. Purification by flash chromatography (silica gel, 20% EtoAc/hexane) yielded 4.25 g (0.013 mol, 42.6%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05278326 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-fa21657dea704b76b15b893bf8205caa |
| Source note | uspto-grants-1994_01 |