HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-methyl-1H-indol-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Cyclohexene | HCID 8079 | — |
| Reactant | 6-(Benzyloxy)-1-methyl-1H-indole | HCID 12348384 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Diisopropyl Ether | HCID 7914 | — |
| Product | 1-methyl-1H-indol-6-ol | HCID 12203496 | — |
Reaction Steps
The mixture consisting of 0.24 mole (57 g) of 6-benzyloxy-1-methylindole, 5.7 g of 10% palladium-on-charcoal, 114 ml of cyclohexene and 170 ml of 96% ethanol is heated for 30 minutes under reflux. The mixture is filtered hot to remove the catalyst. After evaporation of the filtrate under vacuum, an oil is obtained which, dissolved in isopropyl ether, gives the desired product after evaporation to dryness. It melts at 74° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05279620 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-c8d3e5c97ada4d048c5411a371550955 |
| Source note | uspto-grants-1994_01 |