1-Bromohexane → HCID 10765979, compound

HRID 1198106Notes

Reaction equation

HRID 1198106 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:20]=[C:21]([C:24]([CH3:27])([CH3:26])[CH3:25])[C:22]=1[OH:23])[C:8]1[O:9][C:10]2[C:15]([C:16](=[O:18])[CH:17]=1)=[CH:14][CH:13]=[C:12]([OH:19])[CH:11]=2)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])O.[K+].Br[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39]>CN(C)C=O>[C:1]([C:5]1[CH:6]=[C:7]([CH:20]=[C:21]([C:24]([CH3:27])([CH3:26])[CH3:25])[C:22]=1[OH:23])[C:8]1[O:9][C:10]2[C:15]([C:16](=[O:18])[CH:17]=1)=[CH:14][CH:13]=[C:12]([O:19][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[CH:11]=2)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 81011-BromohexaneHCID 516893Potassium BicarbonateHCID 10021812HCID 10021812, compound

Product 1

HCID 10765979HCID 10765979, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.183 g (0.5 mmol) of the compound of Example 1 and 0.25 g (2.5 mmol) of potassium hydrogen carbonate are stirred for a few moments in 10 ml of dimethylformamide at 110° C. under nitrogen until they have completely dissolved. 0.7 ml (5 mmol) of [1-bromo-n-hexane] are then added and the reaction is continued under the same conditions for two hours.

Workup

  1. dissolutionhave completely dissolved

Sources & evidence

ORD record
ord-12d64cd52fa84d1e968c1d0b6925b95a
Source dataset
uspto-grants-1994_01
Patent number
US05280024

Reaction notes

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